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Analysis of hepatitis C virus decline during treatment with the protease inhibitor danoprevir using a multiscale model.

The current paradigm for studying hepatitis C virus (HCV) dynamics in patients utilizes a standard viral dynamic model that keeps track of uninfected (target) cells, infected cells, and virus. The model does not account for the dynamics of intracellular viral replication, which is the major target o...

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Detalhes bibliográficos
Main Authors: Libin Rong, Jeremie Guedj, Harel Dahari, Daniel J Coffield, Micha Levi, Patrick Smith, Alan S Perelson
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science (PLoS) 2013-01-01
Colecção:PLoS Computational Biology
Acesso em linha:http://europepmc.org/articles/PMC3597560?pdf=render
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