Detecting DNA Modifications from SMRT Sequencing Data by Modeling Sequence Context Dependence of Polymerase Kinetic

DNA modifications such as methylation and DNA damage can play critical regulatory roles in biological systems. Single molecule, real time (SMRT) sequencing technology generates DNA sequences as well as DNA polymerase kinetic information that can be used for the direct detection of DNA modifications....

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Detalles Bibliográficos
Main Authors: Feng, Zhixing, Fang, Gang, Korlach, Jonas, Clark, Tyson, Luong, Khai, Zhang, Xuegong, Wong, Wing, Schadt, Eric
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2013
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597545/
https://ncbi.nlm.nih.gov/pubmed/23516341
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002935
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