Defining the sequence requirements for the positioning of base J in DNA using SMRT sequencing

Base J (β-D-glucosyl-hydroxymethyluracil) replaces 1% of T in the Leishmania genome and is only found in telomeric repeats (99%) and in regions where transcription starts and stops. This highly restricted distribution must be co-determined by the thymidine hydroxylases (JBP1 and JBP2) that catalyze...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Genest, Paul-Andre, Baugh, Loren, Taipale, Alex, Zhao, Wanqi, Jan, Sabrina, van Luenen, Henri G.A.M., Korlach, Jonas, Clark, Tyson, Luong, Khai, Boitano, Matthew, Turner, Steve, Myler, Peter J., Borst, Piet
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
Assuntos:
Gene regulation, Chromatin and Epigenetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4344527/
https://ncbi.nlm.nih.gov/pubmed/25662217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv095
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