Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

Many studies have proved that oncogenic viruses develop redundant mechanisms to alter the functions of the tumor suppressor p53. Here we show that Epstein-Barr virus (EBV), via the oncoprotein LMP-1, induces the expression of ΔNp73α, a strong antagonist of p53. This phenomenon is mediated by the LMP...

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Hlavní autoři: Accardi, Rosita, Fathallah, Ikbal, Gruffat, Henri, Mariggiò, Giuseppe, Le Calvez-Kelm, Florence, Voegele, Catherine, Bartosch, Birke, Hernandez-Vargas, Hector, McKay, James, Sylla, Bakary S., Manet, Evelyne, Tommasino, Massimo
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597522/
https://ncbi.nlm.nih.gov/pubmed/23516355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003186
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