Epstein - Barr Virus Transforming Protein LMP-1 Alters B Cells Gene Expression by Promoting Accumulation of the Oncoprotein ΔNp73α

Many studies have proved that oncogenic viruses develop redundant mechanisms to alter the functions of the tumor suppressor p53. Here we show that Epstein-Barr virus (EBV), via the oncoprotein LMP-1, induces the expression of ΔNp73α, a strong antagonist of p53. This phenomenon is mediated by the LMP...

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Main Authors: Accardi, Rosita, Fathallah, Ikbal, Gruffat, Henri, Mariggiò, Giuseppe, Le Calvez-Kelm, Florence, Voegele, Catherine, Bartosch, Birke, Hernandez-Vargas, Hector, McKay, James, Sylla, Bakary S., Manet, Evelyne, Tommasino, Massimo
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597522/
https://ncbi.nlm.nih.gov/pubmed/23516355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003186
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