Regional white matter hyperintensity volume, not hippocampal atrophy, predicts incident Alzheimer’s disease in the community

BACKGROUND: New onset Alzheimer’s disease (AD) is often attributed to degenerative changes in the hippocampus. However, the contribution of regionally distributed small vessel cerebrovascular disease, visualized as white matter hyperintensities (WMH) on MRI, remains unclear. OBJECTIVE: To determine...

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Main Authors: Brickman, Adam M., Provenzano, Frank A., Muraskin, Jordan, Manly, Jennifer J., Blum, Sonja, Apa, Zoltan, Stern, Yaakov, Brown, Truman R., Luchsinger, José A., Mayeux, Richard
Format: Artigo
Sprog:Inglês
Udgivet: 2012
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597387/
https://ncbi.nlm.nih.gov/pubmed/22945686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/archneurol.2012.1527
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