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Enantioselective Synthesis of Atropisomeric Benzamides through Peptide-Catalyzed Bromination

We report the enantioselective synthesis of atropisomeric benzamides employing catalytic electrophilic aromatic substitution reactions involving bromination. The catalyst is a simple tetrapeptide bearing a tertiary amine that may function as a Brønsted base. A series of tri- and dibrominations are a...

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Hlavní autoři: Barrett, Kimberly T., Miller, Scott J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596792/
https://ncbi.nlm.nih.gov/pubmed/23410090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400082x
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