A combined oncogenic pathway signature of BRAF, KRAS and PI3KCA mutation improves colorectal cancer classification and cetuximab treatment prediction

OBJECTIVE: To develop gene expression profiles that characterise KRAS-, BRAF- or PIK3CA-activated- tumours, and to explore whether these profiles might be helpful in predicting the response to the epidermal growth factor receptor (EGFR) pathway inhibitors better than mutation status alone. DESIGN: F...

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Autors principals: Tian, Sun, Simon, Iris, Moreno, Victor, Roepman, Paul, Tabernero, Josep, Snel, Mireille, van't Veer, Laura, Salazar, Ramon, Bernards, Rene, Capella, Gabriel
Format: Artigo
Idioma:Inglês
Publicat: BMJ Group 2013
Matèries:
Colon
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596735/
https://ncbi.nlm.nih.gov/pubmed/22798500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2012-302423
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