Decoupling of DNA damage response signaling from DNA damages underlies temozolomide resistance in glioblastoma cells()

Glioblastoma multiforme (GBM) is the most aggressive primary brain tumor in adults. Current therapy includes surgery, radiation and chemotherapy with temozolomide (TMZ). Major determinants of clinical response to TMZ include methylation status of the O6-methylguanine-DNA methyltransferase (MGMT) pro...

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Hlavní autoři: Cui, Bo, Johnson, Stewart P., Bullock, Nancy, Ali-Osman, Francis, Bigner, Darell D., Friedman, Henry S.
Médium: Artigo
Jazyk:Inglês
Vydáno: Editorial Department of Journal of Biomedical Research 2010
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596690/
https://ncbi.nlm.nih.gov/pubmed/23554659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1674-8301(10)60057-7
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