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A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells
PURPOSE: Sphingosine kinase is an oncogene that is up-regulated in several solid tumors. The product of the sphingosine kinase activity, sphingosine-1-phosphate is a potent mitogen involved in diverse cell processes such as cell survival and migration. Current standard therapy in the treatment of gl...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2009
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3674501/ https://ncbi.nlm.nih.gov/pubmed/19597728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1063-0 |
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