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A sphingosine kinase inhibitor induces cell death in temozolomide resistant glioblastoma cells

PURPOSE: Sphingosine kinase is an oncogene that is up-regulated in several solid tumors. The product of the sphingosine kinase activity, sphingosine-1-phosphate is a potent mitogen involved in diverse cell processes such as cell survival and migration. Current standard therapy in the treatment of gl...

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Main Authors: Bektas, Meryem, Johnson, Stewart P., Poe, William E., Bigner, Darell D., Friedman, Henry S.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3674501/
https://ncbi.nlm.nih.gov/pubmed/19597728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-009-1063-0
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