Mismatch Repair Deficiency Does Not Mediate Clinical Resistance to Temozolomide in Malignant Glioma

PURPOSE: A major mechanism of resistance to methylating agents, including temozolomide, is the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (AGT). Preclinical data indicates that defective DNA mismatch repair (MMR) results in tolerance to temozolomide regardless of AGT activity. The pur...

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Detalhes bibliográficos
Main Authors: Maxwell, Jill A., Johnson, Stewart P., McLendon, Roger E., Lister, David W., Horne, Krystle S., Rasheed, Ahmed, Quinn, Jennifer A., Ali-Osman, Francis, Friedman, Allan H., Modrich, Paul L., Bigner, Darell D., Friedman, Henry S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2830553/
https://ncbi.nlm.nih.gov/pubmed/18676759
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-4807
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