Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.
GCN4 encodes a transcriptional activator of amino acid-biosynthetic genes in Saccharomyces cerevisiae that is regulated at the translational level by upstream open reading frames (uORFs) in its mRNA leader. uORF4 (counting from the 5' end) is sufficient to repress GCN4 under nonstarvation conditions...
Shranjeno v:
| izdano v: | Mol Cell Biol |
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| Principais autores: | , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Taylor & Francis
1991
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1986242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.1.486-496.1991 |
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