Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control.

GCN4 encodes a transcriptional activator of amino acid-biosynthetic genes in Saccharomyces cerevisiae that is regulated at the translational level by upstream open reading frames (uORFs) in its mRNA leader. uORF4 (counting from the 5' end) is sufficient to repress GCN4 under nonstarvation conditions...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Abastado, J P, Miller, P F, Jackson, B M, Hinnebusch, A G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1991
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359655/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1986242/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.11.1.486-496.1991
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