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Synthesis and evaluation of the aldolase antibody-derived chemical-antibodies targeting alpha(5)beta(1) integrin
Integrin α5β1 is an important therapeutic target that can be inhibited using an aldolase antibody (Ab)-derived chemical-Ab (chem-Ab) for the treatment of multiple human diseases, including cancers. A fairly optimized anti-integrin α5β1 chem-Ab 38C2-4e was obtained using an in situ convergent chemica...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3596504/ https://ncbi.nlm.nih.gov/pubmed/23102054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp3004463 |
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