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Mitochondrial Biogenesis Drives a Vicious Cycle of Metabolic Insufficiency and Mitochondrial DNA Deletion Mutation Accumulation in Aged Rat Skeletal Muscle Fibers

Aged muscles possess dysfunctional fibers that contain intracellular expansions of somatically derived mitochondrial DNA deletion mutations. At high abundance, these mutations disrupt the expression of mitochondrially-encoded protein subunits of the electron transport chain resulting in aerobic resp...

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Bibliografiske detaljer
Main Authors: Herbst, Allen, Johnson, Chad J., Hynes, Kayla, McKenzie, Debbie, Aiken, Judd M.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596334/
https://ncbi.nlm.nih.gov/pubmed/23516592
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0059006
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