Mitochondrial DNA deletion mutations increase exponentially with age in human skeletal muscle

BACKGROUND: Mitochondrial DNA (mtDNA) deletion mutations lead to electron transport chain deficient cells and age-induced cell loss in multiple tissues and mammalian species. Accurate quantitation of somatic mtDNA deletion mutations could serve as an index of age-induced cell loss. Quantitation of m...

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Detalhes bibliográficos
Publicado no:Aging Clin Exp Res
Main Authors: Herbst, Allen, Lee, Cathy C., Vandiver, Amy R., Aiken, Judd M., McKenzie, Debbie, Hoang, Austin, Allison, David, Liu, Nianjun, Wanagat, Jonathan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7985047/
https://ncbi.nlm.nih.gov/pubmed/32965609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40520-020-01698-7
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