Treatment of Arthritis by Macrophage Depletion and Immunomodulation: Testing an Apoptosis-Mediated Therapy in a Humanized Death Receptor Mouse Model

OBJECTIVE: To determine the therapeutic efficacy and immunomodulatory effect of an anti-human death receptor 5 (DR5) antibody, TRA-8, in eliminating macrophage subsets in a collagen II-induced arthritis (CIA) mouse model. METHODS: A chimeric human/mouse (hu/mo) DR5 transgenic (Tg) mouse, under the r...

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Hlavní autoři: Li, Jun, Hsu, Hui-Chen, Yang, PingAr, Wu, Qi, Li, Hao, Edgington, Laura E., Bogyo, Matthew, Kimberly, Robert P., Mountz, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3596268/
https://ncbi.nlm.nih.gov/pubmed/22006294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33423
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