GSK3β Phosphorylates Newly Identified Site in the Pro-Ala Rich Region of Cardiac Myosin Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human

RATIONALE: Cardiac myosin binding protein C (cMyBP-C) regulates cross-bridge cycling kinetics and thereby fine-tunes the rate of cardiac muscle contraction and relaxation. Its effects on cardiac kinetics are modified by phosphorylation. Three phosphorylation sites (Ser275, Ser284, Ser304) have been...

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Autores principales: Kuster, Diederik W.D., Sequeira, Vasco, Najafi, Aref, Boontje, Nicky M., Wijnker, Paul J.M., Witjas-Paalberends, E. Rosalie, Marston, Steven B., dos Remedios, Cristobal G., Carrier, Lucie, Demmers, Jeroen A.A., Redwood, Charles, Sadayappan, Sakthivel, van der Velden, Jolanda
Formato: Artigo
Lenguaje:Inglês
Publicado: 2012
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3595322/
https://ncbi.nlm.nih.gov/pubmed/23277198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.112.275602
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