ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Diastolic dysfunction is general to all idiopathic dilated (IDCM) and hypertrophic cardiomyopathy (HCM) patients. Relaxation deficits may result from increased actin–myosin formation during diastole due to altered tropomyosin position, which blocks myosin binding to actin in the absence of Ca(2+). W...

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書目詳細資料
發表在:Proc Natl Acad Sci U S A
Main Authors: Sequeira, Vasco, Najafi, Aref, Wijnker, Paul J. M., dos Remedios, Cristobal G., Michels, Michelle, Kuster, Diederik W. D., van der Velden, Jolanda
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2015
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PNAS Plus
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687530/
https://ncbi.nlm.nih.gov/pubmed/26621701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513843112
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