ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Diastolic dysfunction is general to all idiopathic dilated (IDCM) and hypertrophic cardiomyopathy (HCM) patients. Relaxation deficits may result from increased actin–myosin formation during diastole due to altered tropomyosin position, which blocks myosin binding to actin in the absence of Ca(2+). W...

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Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sequeira, Vasco, Najafi, Aref, Wijnker, Paul J. M., dos Remedios, Cristobal G., Michels, Michelle, Kuster, Diederik W. D., van der Velden, Jolanda
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2015
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687530/
https://ncbi.nlm.nih.gov/pubmed/26621701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513843112
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