ADP-stimulated contraction: A predictor of thin-filament activation in cardiac disease

Diastolic dysfunction is general to all idiopathic dilated (IDCM) and hypertrophic cardiomyopathy (HCM) patients. Relaxation deficits may result from increased actin–myosin formation during diastole due to altered tropomyosin position, which blocks myosin binding to actin in the absence of Ca(2+). W...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Sequeira, Vasco, Najafi, Aref, Wijnker, Paul J. M., dos Remedios, Cristobal G., Michels, Michelle, Kuster, Diederik W. D., van der Velden, Jolanda
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4687530/
https://ncbi.nlm.nih.gov/pubmed/26621701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1513843112
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