A Triple-Transgenic Immunotolerant Mouse Model

Avoiding unwanted immunogenicity is of key importance in the development of therapeutic drug proteins. Animal models are of less predictive value because most of the drug proteins are recognized as foreign proteins. However, different methods have been developed to obtain immunotolerant animal model...

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Bibliografiska uppgifter
Huvudupphovsmän: Brenden, Nina, Madeyski-Bengtson, Katja, Martinsson, Klara, Svärd, Rebecka, Albery-Larsdotter, Sara, Granath, Britta, Lundgren, Hanna, Lövgren, Ann
Materialtyp: Artigo
Språk:Inglês
Publicerad: Wiley Subscription Services, Inc., A Wiley Company 2013
Ämnen:
Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594975/
https://ncbi.nlm.nih.gov/pubmed/23316010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23447
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