A Triple-Transgenic Immunotolerant Mouse Model

Avoiding unwanted immunogenicity is of key importance in the development of therapeutic drug proteins. Animal models are of less predictive value because most of the drug proteins are recognized as foreign proteins. However, different methods have been developed to obtain immunotolerant animal model...

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Autors principals: Brenden, Nina, Madeyski-Bengtson, Katja, Martinsson, Klara, Svärd, Rebecka, Albery-Larsdotter, Sara, Granath, Britta, Lundgren, Hanna, Lövgren, Ann
Format: Artigo
Idioma:Inglês
Publicat: Wiley Subscription Services, Inc., A Wiley Company 2013
Matèries:
Pharmacokinetics, Pharmacodynamics and Drug Transport and Metabolism
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594975/
https://ncbi.nlm.nih.gov/pubmed/23316010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.23447
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