Inhibition of NF-κB by Dehydroxymethylepoxyquinomicin Suppresses Invasion and Synergistically Potentiates Temozolomide and γ-Radiation Cytotoxicity in Glioblastoma Cells

Despite advances in neurosurgery and aggressive treatment with temozolomide (TMZ) and radiation, the overall survival of patients with glioblastoma (GBM) remains poor. Vast evidence has indicated that the nuclear factor NF-κB is constitutively activated in cancer cells, playing key roles in growth a...

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Main Authors: Brassesco, M. S., Roberto, G. M., Morales, A. G., Oliveira, J. C., Delsin, L. E. A., Pezuk, J. A., Valera, E. T., Carlotti, C. G., Rego, E. M., de Oliveira, H. F., Scrideli, C. A., Umezawa, K., Tone, L. G.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594939/
https://ncbi.nlm.nih.gov/pubmed/23533755
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/593020
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