Inhibition of Polo-Like Kinase 1 Induces Cell Cycle Arrest and Sensitizes Glioblastoma Cells to Ionizing Radiation

Despite efforts to improve surgical, radiologic, and chemotherapeutic strategies, the outcome of patients with glioblastoma (GBM) is still poor. Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays key roles in cell cycle control and has been associated with tumor growth and prognosis....

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Detalhes bibliográficos
Main Authors: Pezuk, Julia Alejandra, Brassesco, María Sol, Morales, Andressa Gois, de Oliveira, Jaqueline Carvalho, de Oliveira, Harley Francisco, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741430/
https://ncbi.nlm.nih.gov/pubmed/23713868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2012.1415
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