Inhibition of Polo-Like Kinase 1 Induces Cell Cycle Arrest and Sensitizes Glioblastoma Cells to Ionizing Radiation

Despite efforts to improve surgical, radiologic, and chemotherapeutic strategies, the outcome of patients with glioblastoma (GBM) is still poor. Polo-like kinase 1 (PLK1) is a serine/threonine kinase that plays key roles in cell cycle control and has been associated with tumor growth and prognosis....

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Bibliographic Details
Main Authors: Pezuk, Julia Alejandra, Brassesco, María Sol, Morales, Andressa Gois, de Oliveira, Jaqueline Carvalho, de Oliveira, Harley Francisco, Scrideli, Carlos Alberto, Tone, Luiz Gonzaga
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2013
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3741430/
https://ncbi.nlm.nih.gov/pubmed/23713868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/cbr.2012.1415
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