SH1 domain autophosphorylation of P210 BCR/ABL is required for transformation but not growth factor independence.

P210 BCR/ABL is a chimeric oncogene implicated in the pathogenesis of chronic myelogenous leukemia. BCR sequences have been shown to be required for activation of the tyrosine kinase and transforming functions of BCR/ABL. In this work, we show that two other structural requirements for full transfor...

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Hlavní autoři: Pendergast, A M, Gishizky, M L, Havlik, M H, Witte, O N
Médium: Artigo
Jazyk:Inglês
Vydáno: 1993
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC359485/
https://ncbi.nlm.nih.gov/pubmed/8441409
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