SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

src homology 2 (SH2) domains of intracellular signaling molecules such as phospholipase C-gamma and phosphatidylinositol 3'-kinase-associated protein p85 represent recognition motifs for specific phosphotyrosine-containing regions on activated growth factor receptors. The binding of SH2 domains...

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Detalhes bibliográficos
Main Authors: Felder, S, Zhou, M, Hu, P, Ureña, J, Ullrich, A, Chaudhuri, M, White, M, Shoelson, S E, Schlessinger, J
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC359455/
https://ncbi.nlm.nih.gov/pubmed/7680095
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