SH2 domains exhibit high-affinity binding to tyrosine-phosphorylated peptides yet also exhibit rapid dissociation and exchange.

src homology 2 (SH2) domains of intracellular signaling molecules such as phospholipase C-gamma and phosphatidylinositol 3'-kinase-associated protein p85 represent recognition motifs for specific phosphotyrosine-containing regions on activated growth factor receptors. The binding of SH2 domains to a...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Felder, S, Zhou, M, Hu, P, Ureña, J, Ullrich, A, Chaudhuri, M, White, M, Shoelson, S E, Schlessinger, J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359455/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7680095/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.13.3.1449-1455.1993
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