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A general assay for monitoring the activities of protein tyrosine phosphatases in living eukaryotic cells

Protein tyrosine phosphatases (PTPs) are key signal-transduction regulators and have emerged as potential drug targets for inhibitor design. Here we report a yeast-based assay that provides a general means of assessing the activity and/or inhibition of essentially any classical PTP in living cells....

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Detalhes bibliográficos
Main Authors: Harris, Leigh K., Frumm, Stacey M., Bishop, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3594370/
https://ncbi.nlm.nih.gov/pubmed/23333221
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2012.12.025
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