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Generation of inhibitor-sensitive protein tyrosine phosphatases via active-site mutations
Protein tyrosine phosphatases (PTPs) catalyze the dephosphorylation of phosphotyrosine, a central control element in mammalian signal transduction. Small-molecule inhibitors that are specific for each cellular PTP would be valuable tools in dissecting phosphorylation networks and for validating PTPs...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950444/ https://ncbi.nlm.nih.gov/pubmed/17532515 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2007.02.005 |
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