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Allele-specific inhibition of divergent protein tyrosine phosphatases with a single small molecule

A central challenge of chemical biology is the development of small-molecule tools for controlling protein activity in a target-specific manner. Such tools are particularly useful if they can be systematically applied to the members of large protein families. Here we report that protein tyrosine pho...

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Detalhes bibliográficos
Main Authors: Zhang, Xin-Yu, Chen, Vincent L., Rosen, Mari S., Blair, Elizabeth R., Lone, Anna Mari, Bishop, Anthony C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2561268/
https://ncbi.nlm.nih.gov/pubmed/18678493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.07.053
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