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Acetylation Limits 53BP1 Association with Damaged Chromatin to Promote Homologous Recombination
The pathogenic sequelae of BRCA1 mutation in human and mouse cells are mitigated by concomitant deletion of 53BP1, which binds histone H4 dimethylated at Lys20 (H4K20me2) to promote nonhomologous end-joining, suggesting a balance between BRCA1 and 53BP1 regulates DNA double-strand break (DSB) repair...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594358/ https://ncbi.nlm.nih.gov/pubmed/23377543 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2499 |
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