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An SCF complex containing Fbxl12 mediates DNA damage-induced Ku80 ubiquitylation
The Ku heterodimer, composed of Ku70 and Ku80, is the initiating factor of the nonhomologous end joining (NHEJ) double-strand break (DSB) repair pathway. Ku is also thought to impede the homologous recombination (HR) repair pathway via inhibition of DNA end resection. Using the cell-free Xenopus lae...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
Landes Bioscience
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594259/ https://ncbi.nlm.nih.gov/pubmed/23324393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.23408 |
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