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RNA Interference Targeting CUG Repeats in a Mouse Model of Myotonic Dystrophy
Myotonic dystrophy type 1 (DM1) is an RNA dominant disease caused by expression of DM protein kinase (DMPK) transcripts that contain an expanded CUG repeat (CUG(exp)). The toxic mRNA localizes to nuclear foci and sequesters proteins involved in the regulation of alternative splicing, such as, muscle...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Nature Publishing Group
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3594017/ https://ncbi.nlm.nih.gov/pubmed/23183533 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2012.222 |
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