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Reversal of RNA missplicing and myotonia after muscleblind overexpression in a mouse poly(CUG) model for myotonic dystrophy

RNA-mediated pathogenesis is a recently developed disease model that proposes that certain types of mutant genes produce toxic transcripts that inhibit the activities of specific proteins. This pathogenesis model was proposed first for the neuromuscular disease myotonic dystrophy (DM), which is asso...

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Detalhes bibliográficos
Main Authors: Kanadia, Rahul N., Shin, Jihae, Yuan, Yuan, Beattie, Stuart G., Wheeler, Thurman M., Thornton, Charles A., Swanson, Maurice S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1544241/
https://ncbi.nlm.nih.gov/pubmed/16864772
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0604970103
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