Dynamic Combinatorial Selection of Molecules Capable of Inhibiting the (CUG) Repeat RNA – MBNL1 Interaction in vitro: Discovery of Lead Compounds Targeting Myotonic Dystrophy (DM1)

Myotonic dystrophy type 1 (DM1), the most common form of muscular dystrophy in adults, is an RNA-mediated disease. Dramatically expanded (CUG) repeats accumulate in nuclei, and sequester RNA-binding proteins such as the splicing regulator MBNL1. We have employed resin-bound dynamic combinatorial che...

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Hlavní autoři: Gareiss, Peter C., Sobczak, Krzysztof, McNaughton, Brian R., Palde, Prakash B., Thornton, Charles A., Miller, Benjamin L
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2645920/
https://ncbi.nlm.nih.gov/pubmed/18998634
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja804398y
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