Combined targeting of MEK and PI3K/mTOR effector pathways is necessary to effectively inhibit NRAS mutant melanoma in vitro and in vivo

Activating mutations in the neuroblastoma rat sarcoma viral oncogene homolog (NRAS) gene are common genetic events in malignant melanoma being found in 15–25% of cases. NRAS is thought to activate both mitogen activated protein kinase (MAPK) and PI3K signaling in melanoma cells. We studied the influ...

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Detalhes bibliográficos
Main Authors: Posch, Christian, Moslehi, Homayoun, Feeney, Luzviminda, Green, Gary A., Ebaee, Anoosheh, Feichtenschlager, Valentin, Chong, Kim, Peng, Lily, Dimon, Michelle T., Phillips, Thomas, Daud, Adil I., McCalmont, Timothy H., LeBoit, Philip E., Ortiz-Urda, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593920/
https://ncbi.nlm.nih.gov/pubmed/23431193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216013110
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