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MEK/CDK4,6 co-targeting is effective in a subset of NRAS, BRAF and ‘wild type’ melanomas

Targeted therapy has become a cornerstone for the treatment of melanoma patients. Targeting NRAS function is particularly challenging. To date, only single MEK inhibitor treatment was able to show minimal clinical efficacy. The discovery that co-targeting of MEK and CDK4,6 has antitumor activity cre...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Posch, Christian, Sanlorenzo, Martina, Ma, Jeffrey, Kim, Sarasa T., Zekhtser, Mitchell, Ortiz-Urda, Susana
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6201855/
https://ncbi.nlm.nih.gov/pubmed/30405888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.26204
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