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DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions
DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functions as a powerful barrier to tumor development. Adult stem cells are resistant to DNA damage-induced apop...
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2013
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3593901/ https://ncbi.nlm.nih.gov/pubmed/23417300 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213394110 |
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