DNA damage in stem cells activates p21, inhibits p53, and induces symmetric self-renewing divisions

DNA damage leads to a halt in proliferation owing to apoptosis or senescence, which prevents transmission of DNA alterations. This cellular response depends on the tumor suppressor p53 and functions as a powerful barrier to tumor development. Adult stem cells are resistant to DNA damage-induced apop...

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Detalhes bibliográficos
Main Authors: Insinga, Alessandra, Cicalese, Angelo, Faretta, Mario, Gallo, Barbara, Albano, Luisa, Ronzoni, Simona, Furia, Laura, Viale, Andrea, Pelicci, Pier Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593901/
https://ncbi.nlm.nih.gov/pubmed/23417300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1213394110
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