Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

Mutations of p53 are remarkably rare in acute promyelocytic leukemias (APLs). Here, we demonstrate that the APL-associated fusion proteins PML–RAR and PLZF-RAR directly inhibit p53, allowing leukemic blasts to evade p53-dependent cancer surveillance pathways. PML–RAR causes deacetylation and degrada...

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Detalhes bibliográficos

Publicado no:	EMBO J
Principais autores:	Insinga, Alessandra, Monestiroli, Silvia, Ronzoni, Simona, Carbone, Roberta, Pearson, Mark, Pruneri, Giancarlo, Viale, Giuseppe, Appella, Ettore, Pelicci, PierGiuseppe, Minucci, Saverio
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Publishing Group 2004
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC380970/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14976551/ https://ncbi.nlm.nih.govhttps://doi.org/10.1038/sj.emboj.7600109
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