Impairment of p53 acetylation, stability and function by an oncogenic transcription factor

Mutations of p53 are remarkably rare in acute promyelocytic leukemias (APLs). Here, we demonstrate that the APL-associated fusion proteins PML–RAR and PLZF-RAR directly inhibit p53, allowing leukemic blasts to evade p53-dependent cancer surveillance pathways. PML–RAR causes deacetylation and degrada...

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Main Authors: Insinga, Alessandra, Monestiroli, Silvia, Ronzoni, Simona, Carbone, Roberta, Pearson, Mark, Pruneri, Giancarlo, Viale, Giuseppe, Appella, Ettore, Pelicci, PierGiuseppe, Minucci, Saverio
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2004
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC380970/
https://ncbi.nlm.nih.gov/pubmed/14976551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600109
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