Molecular basis for manganese sequestration by calprotectin and roles in the innate immune response to invading bacterial pathogens

The S100A8/S100A9 heterodimer calprotectin (CP) functions in the host response to pathogens through a mechanism termed “nutritional immunity.” CP binds Mn(2+) and Zn(2+) with high affinity and starves bacteria of these essential nutrients. Combining biophysical, structural, and microbiological analy...

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Main Authors: Damo, Steven M., Kehl-Fie, Thomas E., Sugitani, Norie, Holt, Marilyn E., Rathi, Subodh, Murphy, Wesley J., Zhang, Yaofang, Betz, Christine, Hench, Laura, Fritz, Günter, Skaar, Eric P., Chazin, Walter J.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593839/
https://ncbi.nlm.nih.gov/pubmed/23431180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220341110
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