Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation.

E2F-1, a member of the E2F transcription factor family, contributes to the regulation of the G1-to-S phase transition in higher eukaryotic cells. E2F-1 forms a heterodimer with DP-1 and binds to several cell cycle regulatory proteins, including the retinoblastoma family (RB, p107, p130) and cyclin A...

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Veröffentlicht in:	Mol Cell Biol
Hauptverfasser:	Xu, M, Sheppard, K A, Peng, C Y, Yee, A S, Piwnica-Worms, H
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC359381/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7969176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.14.12.8420-8431.1994
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