Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycl...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1990
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54198/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2141171/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.12.4766 |
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