Mammalian nonsense codons can be cis effectors of nuclear mRNA half-life.

Frameshift and nonsense mutations within the gene for human triosephosphate isomerase (TPI) that generate a nonsense codon within the first three-fourths of the protein coding region have been found to reduce the abundance of the product mRNA that copurifies with nuclei. The cellular process and loc...

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Bibliographic Details
Main Authors: Belgrader, P, Cheng, J, Zhou, X, Stephenson, L S, Maquat, L E
Format: Artigo
Language:Inglês
Published: 1994
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC359361/
https://ncbi.nlm.nih.gov/pubmed/7969159
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