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Modulation of Cell Surface Expression of Nonactivated Cholecystokinin Receptors Using Bivalent Ligand-Induced Internalization

CCK(2) receptor antagonists potentiate pain relief by MOP receptor agonists. In an attempt to enhance this effect, we prepared bivalent ligands incorporating CCK(2) receptor antagonist and MOP receptor agonist pharmacophores.(9) Ligands with 16- to 22-atom spacers could simultaneously bind both rece...

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Bibliografiske detaljer
Main Authors: Harikumar, Kaleeckal G., Akgün, Eyup, Portoghese, Philip S., Miller, Laurence J.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593351/
https://ncbi.nlm.nih.gov/pubmed/20235611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100135g
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