Removal of the BH4 Domain from Bcl-2 Protein Triggers an Autophagic Process that Impairs Tumor Growth

Here, we show that forced expression of a B-cell lymphoma 2 (bcl-2) protein lacking residues 1 to 36 at the N-terminal, including the entire Bcl-2 homology 4 (BH4) domain, determines reduction of in vitro and in vivo human melanoma growth. Noteworthy, melanoma cells in vivo exhibit markedly increase...

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Main Authors: Trisciuoglio, Daniela, De Luca, Teresa, Desideri, Marianna, Passeri, Daniela, Gabellini, Chiara, Scarpino, Stefania, Liang, Chengyu, Orlandi, Augusto, Del Bufalo, Donatella
Format: Artigo
Sprog:Inglês
Udgivet: Neoplasia Press Inc. 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3593154/
https://ncbi.nlm.nih.gov/pubmed/23479509
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