Histone deacetylase inhibition synergistically enhances pemetrexed cytotoxicity through induction of apoptosis and autophagy in non-small cell lung cancer

BACKGROUND: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. Pemetrexed, a multi-target folate antagonist, has demonstrated efficacy in NSCLC histological subtypes characterized by low thymidylate synthase (TS) expression. Among many other potential targets,...

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Detalhes bibliográficos
Main Authors: Del Bufalo, Donatella, Desideri, Marianna, De Luca, Teresa, Di Martile, Marta, Gabellini, Chiara, Monica, Valentina, Busso, Simone, Eramo, Adriana, De Maria, Ruggero, Milella, Michele, Trisciuoglio, Daniela
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4198757/
https://ncbi.nlm.nih.gov/pubmed/25301686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-13-230
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