Mechanism of inhibition of Raf-1 by protein kinase A.

The cytoplasmic Raf-1 kinase is essential for mitogenic signalling by growth factors, which couple to tyrosine kinases, and by tumor-promoting phorbol esters such as 12-O-tetradecanoylphorbol-13-acetate, which activate protein kinase C (PKC). Signalling by the Raf-1 kinase can be blocked by activati...

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Библиографические подробности
Главные авторы: Häfner, S, Adler, H S, Mischak, H, Janosch, P, Heidecker, G, Wolfman, A, Pippig, S, Lohse, M, Ueffing, M, Kolch, W
Формат: Artigo
Язык:Inglês
Опубликовано: 1994
Предметы:
Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC359200/
https://ncbi.nlm.nih.gov/pubmed/7935389
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