Pharmacokinetics, Safety, and Tolerability of GS-9851, a Nucleotide Analog Polymerase Inhibitor for Hepatitis C Virus, following Single Ascending Doses in Healthy Subjects

To investigate the pharmacokinetics, safety, and tolerability of GS-9851 (formerly PSI-7851), a new nucleotide analog inhibitor of hepatitis C virus (HCV), we conducted a double-blind, parallel, placebo-controlled, randomized, single-ascending-dose study. Healthy subjects received oral doses of 25 t...

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Bibliographische Detailangaben
Hauptverfasser: Denning, Jill, Cornpropst, Melanie, Flach, Stephen D., Berrey, Michelle M., Symonds, William T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2013
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3591883/
https://ncbi.nlm.nih.gov/pubmed/23262999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.01262-12
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